Failure to Absorb Vitamin B12 in Dogs - Symptoms, Causes ..

B12 (cobalamin) injections are needed if the dog has very low serum cobalamin. A blood test is required to determine this, costs about $31, and is best done simultaneously with the TLI test. Many EPI dogs cannot replenish B12 levels on their own, so B12 injections are used. B12-complex formulas are not recommended since they contain much lower concentrations of cobalamin and appear to cause pain at the injection sites. Generic formulations of cobalamin (B12) are acceptable.

For use as an aid in the management of vitamin B12 deficiencies in cattle, horses, dogs and cats.

For example, if the testing does come back as consistent with EPI, are you going to start your grey on the expensive medication (pancreatic enzymes) used to treat EPI? With most dogs with EPI, we monitor progress based on weight and appetite, since uncontrolled EPI dogs have a ravenous appetite but lose weight. In your pup's case, I'm not sure what parameter you'd be monitoring to see if the medication is helping. Other than maybe his stool consistency, but using expensive pancreatic enzymes to treat such mild signs would seem a bit overboard to me. Same thought process with giving B12 injections if he does come back low on bloodwork - what would you be looking at to monitor response?

Should I give a Vitamin B12 supplement to my dog? | That Pet Blog

*** Please follow the current TAMU (Texas A&M University) B12 protocol for EPI dogs and cats *** Dietary need depends on intestinal synthesis and tissue reserves at birth. Intestinal synthesis probably explains frequent failures to produce a vitamin B12 deficiency in pigs and rats on diets designed to be vitamin B12 free. The deficiency can be readily produced in rats, however, when coprophagy is prevented completely (Barnes and Fiala, 1958). The dog’s inclination toward coprophagy will supply part of the vitamin B12 requirement. Both dogs and cats likely also obtain some vitamin B12 by direct absorption of the vitamin produced by bacterial synthesis in the intestine. However, the amount from this source is not reliable. Some intestinal microorganisms reportedly may compete with the intrinsic factor for vitamin B12, thus preventing absorption of the vitamin in sufficient quantities (Giannella et al., 1971; 1972). In the dog, hookworm infections can also increase vitamin B12 requirements (Corbin and Kronfeld, 1972).

Jan 29, 2014 - Hi Pet Blog Readers

Genetic factors have been shown to increase the vitamin B12 requirements of both dogs and cats. A diagnosis of hereditary selective vitamin B12 malabsorption in dogs has been reported in border collies, giant schnauzers, Australian shepherd dogs, beagles and Chinese shar peis (Fordyce et al., 2000; Battersby et al., 2005; Grϋtzner et al.,2010). Grϋtzner et al. (2010) observed that the region of chromosome 13 should be mapped and closely examined for potential mutations associated with this disease in the shar peis. Fyfe et al. (1989; 1991a) described a family of dogs with the clinical, genetic and laboratory features of selective intestinal vitamin B12 malabsorption seen in humans. The malabsorption was caused by inefficient brush-border expression of intrinsic factor-vitamin B12 receptor due to a mutation of this complex and its retention (Fyfe et al., 1991b). Vitamin B12 deficiency associated with methylmalonic acidemia has been demonstrated in cats (Vaden et al., 1992). Apparently, this defect in vitamin B12 absorption is the result of an inborn error of metabolism.

Human Vitamins and Supplements for Dogs: Is it Safe? - Pettura