In a margin of safety study, COMFORTIS were administered orally to 6-week-old Beagle puppies at average doses of 1.5, 4.4, and 7.4 times the maximum recommended dose at 28-day intervals over a 6-month period. Vomiting was observed across all groups, including the placebo. Increased vomiting was observed at elevated doses, usually within 1 hour following administration. Vomiting at all doses decreased over time and stabilized when puppies were 14 weeks of age. The average daily and total weight gains of treated dogs were smaller than control dogs and were dose dependent. COMFORTIS was not associated with clinically significant changes in hematology, clinical chemistry, coagulation or urinalysis parameters. Phospholipidosis (vacuolation) of the lymphoid tissue was seen in some dogs in the 4.4 X group and all dogs in the 7.4 X group. The long term effects of phospholipidosis are unknown. Treatment with COMFORTIS was not associated with any other clinically significant adverse clinical observations, gross necropsy or histopathological changes.
Comfortis is safe for puppies and kittens as young as 14 weeks
I am very pleased with 3 german shepherds relief from comfortis I am still having possible tape worm cutaneous or dark freckles that whem put a flea spray onthis dark area notice small dark round furry specks and then with flea comb over same spot small white chunks or specks of different sizes this is on my small white dog. Possibly cant see on large dogs or havent noticed Always seem to have ear mite problems too Tropical area Does anyone know what I;m seeing thanks
One loves small dry treats and eats the pill like any other treat.
I started using Comfortis for my two small dogs almost a year ago. It works PERFECTLY!! Maybe since they’re small (both under 10 lbs) one pill last for a good 6 weeks or longer. By the end of the 1st day, there were NO more fleas on either of my dogs! NONE!! The one thing i have noticed in both of my dogs is occasionally they get a little bit of a cough. Just a dry, annoying little cough…but they do it a lot now. They have both been to the vet & appear to be very healthy so I guess it’s a harmless side effect…much better than fleas!!
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