The pancreatic enzymes have an important role in digestion

My German Shepherd bitch developed Pancreatic insufficiency after have a large litter. This was before pancreatic enzymes were available.
She lived to a good age by being fed a totally fat free diet. That and regular cooked bone. A spongy bone -- it helped to slow her digestion down so that her food remained in her digestive tract long enough to be properly digested and absorbed.
I believe, from things I've read, that the problem was a gross Vitamin B deficiency caused by trying to feed all those pups. All my dogs now get regular Brewers Yeast supplement, increased for the bitches when they are nursing a litter. I've also kept my dogs on a low far diet and still use the same vitamin/mineral supplement that I used for Topsy.

Oct 8, 2012 - Treatment for EPI always includes pancreatic enzyme supplements added to your dog's food to aid healthy digestion

Most dogs and cats with EPI can be successfully treated by supplementation with pancreatic enzymes. Powder is more effective than tablets, capsules, and especially enteric-coated products. Initially, 1 teaspoon/10 kg should be given with each meal for dogs and 1 teaspoon/cat with each meal for cats. Once the clinical signs have completely resolved, the dose can be slowly decreased until the lowest effective dose has been reached. However, it should be noted that the lowest effective dose can vary between enzyme batches. Oral bleeding has been reported in 3 of 25 dogs with EPI treated with pancreatic enzyme supplements; the bleeding stopped in all three dogs after a dose reduction. Moistening the food and pancreatic powder mix may also decrease the frequency of this adverse effect.

They help processing fats, proteins and carbohydrates

Most dogs are treated on an outpatient basis with pancreatic enzyme replacement therapy and dietary supplements Porcine (pig) enzyme powder is the main method used to manage EPI. It is commercially available and easy to use. The enzyme supplements, typically, contain a combination of 3 digestive enzymes (lipase, protease and amylase). The enzyme is mixed with warm water to activate and the food is coated with the enzyme. There are many enzyme brands available (e.g., , , Pancreatin 8X, , etc.); some require a prescription, others do not. Most dogs do equally well on any brand. Powdered forms are more effective than tablets or capsules.

Porcine Pancreatic Replacement Enzymes needed with every meal

Supplements are the most common treatment option, but, according the Raw Dog Journal, "some EPI dogs have allergies and cannot tolerate the ingredients in the most common enzyme supplements. Those owners learn to develop alternative methods such as using plant enzymes, or a different source of pancreatic enzymes such as beef-based (rather than porcine-based). Raw beef, pork, or lamb pancreas can also be used. One to three ounces of raw chopped pancreas can replace one teaspoon of pancreatic extract." (Read the entire article .)

Digestive Enzymes for Dogs: Are They Necessary? – NextGen Dog